In vitro and in vivo studies by Yamaura and colleagues showed that NMN has antioxidant effects against tendinopathy and promotes the expression of SIRT 1 and SIRT 6, known for their anti-aging and anti-inflammatory roles, while reducing the expression of NOX1, NOX4, Il-6, and ROS [22]. The gene discussed is NOX1; the disease is disease of the tendon.