Notably, the Ri pre-treatment of HUVECs also suppressed the expression of ENOS, LINC00607, and TSP1 (Figure 7H,I) and prevented MG adduct-induced endothelial dysfunction, evaluated by endothelial homeostasis via eNOS (Figure 7J) and vascular permeability (Figure 7K). Here, THBS1 is linked to endothelial dysfunction.