Pinostrobin was shown to be a potent 5-LOX inhibitor (IC50 = 0.499 μM) compared to nordihydroguaiaretic acid (NDGA; IC50 = 5.020 μM) and betamethasone dipropionate (BD; IC50 = 2.077 μM) as the first-line of AD treatment. The gene discussed is ALOX5; the disease is Alzheimer disease.