Mechanistically, NRF2 regulates cancer cell proliferation by transcriptionally activating key proteins such as nephronectin (NPNT), bone morphogenetic protein receptor 1A (BMPR1A), insulin-like growth factor 1 (IGF1), integrin beta chain-2 (ITGB2), platelet-derived growth factor C (PDGFC), vascular endothelial growth factor C (VEGFC), and Jagged 1 protein (JAG1) [79]. The gene discussed is JAG1; the disease is cancer.