AKT1 and cancer: Redox-sensitive signaling pathways, including phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT/PKB)/mechanistic target of rapamycin (mTOR), p53, AMPK, hypoxia-inducible factor 1 alpha (HIF-1α) and NRF2, exert significant influence on cancer cell metabolism [112].