IL6 and colitis: Wu et al., 2021 [83] evaluated its protective effect in mice’s colon with DSS-induced colitis, both as a preventive measure and as treatment, and found that EGCG was effective in reducing TNF-α and IL-6 concentration in the colon epithelium, as well as IL-1β, IL-6, IL-8, and TNF-α in the plasma, either when administered before or after colitis induction [83].