HMOX1 and colitis: In a model of colitis induced by dextran sulphate sodium (DSS) in BALB/c mice, puerarin was able to reduce oxidative stress in the colon, with emphasis on reduced lipid peroxidation and the regulation of endogenous enzymatic systems (SOD and CAT activity normalization; prevention of GSH depletion), which were observed to be dependent on normalization of Nfr2, HO-1, and NQO1 expression [81].