However, in the presence of Salmonella infection, the cells that underwent pretreatment with sophy β-glucan displayed a remarkable increase in T-AOC (3 and 12 hpi) and SOD activity in the cell supernatant and SOD activity in the cell lysates, and a notable reduction in MDA concentration in the cell supernatant, showing that sophy β-glucan could enhance the anti-oxidant ability of intestinal epithelial cells against the oxidative stress induced by Salmonella infection. The gene discussed is SOD1; the disease is Salmonella Infections.