Moreover, unlike in the elastase-induced COPD mice, the expression of Dio2 did not change from T3 treatment for 12 days (Supplementary Figure S1G), and it slightly increased from T3 treatment for 2 months (vehicle- and T3 (80 μg/kg)-treated ENaC-Tg mice, p = 0.23, effect size d: 1.05) (Supplementary Figure S1H). The gene discussed is DIO2; the disease is chronic obstructive pulmonary disease.