To deliver DPCA, we utilized a shear‐thinning hydrogel, formed from the self‐assembly of PEG‐DPCA conjugates (see SI methods and Figure S1, Supporting Information).[8] When administered subcutaneously in the back of the neck in adult mice, gradual release of DPCA was found to stabilize HIF‐1α in‐ear hole wounds and induce complete regeneration of both hard and soft tissues of the periodontium.[8, 9, 10] Pursuing a similar treatment regimen, in this study we administered doses of PEG‐DPCA gel in the DSS‐induced colitis model on day −2 (before DSS exposure) and day 5 (during DSS exposure). Here, HIF1A is linked to colitis.