To fulfill this unmet need, in this study we attempt to leverage the PHD inhibitor molecule DPCA, which was previously shown to induce regeneration in adult mice through transient stabilization of the transcription factor HIF‐1α.[7, 8, 9, 10] Given past work on DPCA‐induced regeneration and the role of HIF‐1α in intestinal homeostasis, we hypothesized that transient delivery of DPCA would expedite colon repair and disease recovery in experimental colitis. Here, HIF1A is linked to colitis.