RXRA and hepatocellular carcinoma: Moreover, YTHDF2 controls NK cell homeostasis, maturation, and survival at a steady–state.[50] Depletion of Ythdf2 in murine myeloid‐derived suppressor cells significantly enhances the suppressive function of these cells by modulating the degradation of Rxra, thus attenuating ConA‐induced liver injury.[51] We showed that YTHDF2 promoted HCC immune evasion by upregulating ETV5, which induced the transcription of PD‐L1.