To figure out the functions of YTHDF2 in HCC formation and progression, we generated hepatocyte‐specific Ythdf2‐knockout mice (Ythdf2LKO) by crossing albumin‐Cre mice with Ythdf2fl/fl mice (Figure S3A,B, Supporting Information) and administered diethylnitrosamine (DEN)/carbon tetrachloride (CCl4) to induce HCC formation (Figure 2A). The gene discussed is ALB; the disease is hepatocellular carcinoma.