YTHDF2 and hepatocellular carcinoma: In the present study, we demonstrated that the expression of YTHDF2 was aberrantly enhanced by trimethylated histone H3 lysine 4 (H3K4me3) and H3 lysine 27 acetylation (H3K27ac) modification of its promoter region, and increased YTHDF2 expression indicated a poor prognosis for HCC patients.