Polysome profiling coupled with qRT‐PCR verified that the relative distribution of ETV5 mRNA, but not hypoxanthine phosphoribosyltransferase 1 (HPRT1, a nonm6A‐modified mRNA), was shifted from polysome (translation active) toward subpolysome (translation inactive) fractions in YTHDF2‐knockdown HCC cells, and vice versa (Figure 5B; Figure S8A, Supporting Information). This evidence concerns the gene ETV5 and hepatocellular carcinoma.