Hypoxia in the tumor mass decreased YTHDF2 expression to induce interleukin 11‐mediated inflammation‐cancer formation processes and serpin family E member 2‐mediated disruption of vascular normalization, thereby facilitating HCC formation and metastasis.[15] Additionally, hypoxia‐induced YTHDF2 expression inhibited cell proliferation and growth by accelerating the degradation of epidermal growth factor receptor mRNA.[16] However, Yang et al. Here, SERPINE2 is linked to hepatocellular carcinoma.