The Ly6Clo macrophages in the Mφtgmif‐treated group were significantly increased with the high regulation of CX3CL1, suggesting that CX3CL1 could promote Ly6Chi pro‐inflammatory macrophages maturation into Ly6Clo restorative macrophages.[19] Infusion Mφtgmif upregulated the MMP/TIMP ratio to degrade the extracellular matrix and reduce liver fibrosis. The gene discussed is TIMP1; the disease is Hepatic fibrosis.