The increase in PPAR\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\gamma$$\end{document}γ and the decrease in UCP1 expression represent an increase in fat synthesis and storage, as well as a decrease in energy consumption in obese mice, which is consistent with the developmental mechanism of obesity. The gene discussed is PPARA; the disease is obesity due to melanocortin 4 receptor deficiency.