CREBBP and familial pancreatic carcinoma: For instance, in pancreatic cancer, LINC00261 has been shown to suppress c-Myc transcription by obstructing p300/CBP (CREB binding protein, cAMP response element-binding protein) recruitment to the c-Myc promoter region and diminishing H3K27Ac levels through direct interaction with p300/CBP’s brominated structural domain [46].