IGFBP1 and colorectal carcinoma: Multivariate Cox analysis further demonstrated that M stage (P = 0.010, HR = 3.811, 95%CI 1.373–10.580), TNM stage (P = 0.007, HR = 3.106, 95%CI 1.363–7.077) and serum IGFBP-1 (P = 0.045, HR = 2.043, 95%CI 1.014–4.115) were independent factors to predict the prognosis of CRC (Table 4).