IGFBP1 and colorectal carcinoma: In addition, with the same cutoff value, IGFBP-1 could discriminate early-stage CRC from normal controls with a slightly lower AUC value of 0.812 (95% CI 0.795–0.908), a specificity of 90.53% and a sensitivity of 58.82% (Fig. 3 and Table 1).