IGFBP1 and colorectal carcinoma: The mean concentration of serum IGFBP-1 was 1569.455 ± 770.209 ng/mL, 1512.222 ± 818.971 ng/mL and 719.991 ± 379.340 ng/mL in CRC group (n = 138), early-stage CRC group (n = 68) and normal group (n = 190), respectively (Supplementary Table S2).