We examined the molecular architecture of ES-related circuitry in CML cells further using bulk and scRNA-seq datasets obtained from BCR::ABL1− and BCR::ABL1+ primitive bone marrow (BM) cells from a BCR::ABL1 transgenic murine model of CML and from CML patients28. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.