To reconcile these findings, we showed that p53 may exert negative feedback on the ESC-REG; combined NIL plus IDASA treatment of the WT p53 BV173 CML cell line led to increased p53 while decreasing c-MYC, a key regulator of the ESC-REG (Fig. 3b). The gene discussed is TP53; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.