Given that c-MYC is predicted to be a key modulator of the ESC-REG in CML LSC, and that activation of p53 is associated with down-regulation of c-MYC and the ESC-REG (Fig. 3b, e), we cannot overlook the possibility that c-MYC and the ESC-REG also have roles in LSC self-renewal. Here, TP53 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.