To investigate novel downstream molecules, three bioinformatics databases (miRWalk, TargetScan, and miRDB) and osteoporosis-related genes (OP-related genes) were used to determine the potential miR-6359 targets, and SIRT3, SET, WWTR1 and DMD were selected (Fig. 3a). This evidence concerns the gene SIRT3 and osteoporosis.