In ovarian and endometrial cancers, it can promote cancer cell proliferation and induce cancer progression through the canonical Wnt-β-catenin pathway.12 However, in gastric carcinoma, WNT7A acts as a tumor suppressor and is independent of the canonical Wnt-β-catenin signaling.13 Recent studies have shown that WNT7A is upregulated in tongue squamous cell carcinoma (TSCC) and may be involved in the regulation of cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in TSCC.14 The gene discussed is WNT7A; the disease is tongue squamous cell carcinoma.