Mantel-Cox inspection and analysis showed that WNT7A was expressed at higher levels in HNSCC compared to para-cancerous tissues (P < 0.001) (Fig. 1c), and WNT7A expression level was negatively associated with patient overall survival rate (P < 0.001) (Fig. 1d). Here, WNT7A is linked to head and neck squamous cell carcinoma.