IL6 and neoplasm: Our IPA analysis of these downregulated genes revealed their enrichment in pathways such as IL-6 signaling, PTEN signaling and IL-8 signaling, which have been documented to impact HNSCC tumor growth and metastasis.41–43 Building upon the preceding context, we have ascertained that in HNSCC, RNPS1 depletion exerts its tumor growth and metastasis inhibitory function by selectively suppressing the translation of genes involved in signaling pathways like IL-6 signaling.