NAT10 and cancer: Moreover, ac4C is associated with the development, progression, and prognosis of various human diseases, including cancer.8,9 The key enzyme responsible for ac4C as an epitranscriptomics modification is N-acetyltransferase 10 (NAT10).10 However, the mechanisms underlying the interaction between protein partners and NAT10, as well as the binding proteins that regulate NAT10, remain unexplored.