AP infections can trigger a systemic inflammatory response that has been associated with increased oxidative stress and high blood levels of inflammatory biomarkers such as C-reactive protein (CRP), interleukin (IL)-1, IL-2, and IL-6.17, 18, 19, 20, 21, 22 In severe cases, this inflammatory response may even evolve into septicaemia and increase the risk of pathologic conditions such as atherosclerosis,23 cardiovascular disease, and diabetes.24 This evidence concerns the gene CRP and cardiovascular disorder.