Briefly, the synaptic proteins studied appeared to belong to different disease-pattern groups with either decreased levels (e.g., the pentraxins), increased levels (e.g., 14-3-3) in all neurodegenerative diseases, or increased level in AD and decreased in non-AD (e.g., neurogranin, synucleins, and SNAP-25). This evidence concerns the gene SNAP25 and Alzheimer disease.