Other phosphoepitopes, including pS199, pT217, and pT231 as well as the C-terminal residues pS396 and pS404 (51, 52, 53, 54, 55, 56, 57) appear to have different sensitivity and specificity to detect AD, prompting an interest in detailed characterization of tau phosphorylation in AD and other tauopathies to better understand their involvement in the disease process. This evidence concerns the gene MAPT and Alzheimer disease.