Different tauopathies vary in their relative abundance of 3R and 4R in the NFTs, with AD exhibiting a mixture of 3R and 4R, corticobasal syndrome (corticobasal degeneration) and progressive supranuclear palsy containing solely 4R, and Pick’s disease harboring 3R tau only (5, 6, 7). The gene discussed is MAPT; the disease is Alzheimer disease.