GPER1 and metabolic dysfunction-associated steatotic liver disease: In contrast to the phenotypic alterations in HFD-induced NAFLD of GPER1-HKO female mice, the female mice treated with G1 exhibited lower body weight, liver weight, ratios of liver weight to body weight, WAT weight, and ratios of WAT weight to body weight than that of the control mice in response to HFD consumption (Figs. 4A and S8, B and C).