Conversely, with cRaf transgenic animals, orosomucoid 1 (Orm1) is the only immune response gene that is upregulated (threefold, Fig. 2e) and a recent study demonstrated Orm1 to enhance the immunosuppressive function of tumor-associated macrophages (TAMs) (Matsusaka et al. 2021). This evidence concerns the gene RAF1 and neoplasm.