Tobacco smoke exposure of cRaf transgenic mice also caused significant repression of miR-142-5p, miR-146b-5p, miR-16-5p, miR-200b-5p, miR-215-5p, miR-22-3p and miR-335-5p (range 2 to 21-fold), and these tumor suppressors inhibit tumorigenesis, cell proliferation, migration, and enhance sensitivity to cisplatin treatment (Supplementary Table S6). Here, RAF1 is linked to neoplasm.