The other genes commonly upregulated between female transgenic mice and female LC patients were epiregulin, fibrinogen γ, connexin 30 (GJB6) and CD177. Conversely, the only repressed gene commonly regulated between mouse and human lung tumors codes for aminopeptidase N. Based on Kaplan–Meier survival plots, epiregulin is prognostic; its high expression is associated with poor outcome (Fig. 5f). Here, GJB6 is linked to laryngotracheoesophageal cleft.