Indeed, let-7 inhibits LC tumor growth by targeting c-MYC, KRAS and HMGA2 (Johnson et al. 2005; Kolenda et al. 2014), binds to DICER, i.e., a RNAase which processes miRNAs, and induces cell autophagy in LC (Li et al. 2021). This evidence concerns the gene HMGA2 and laryngotracheoesophageal cleft.