In addition, the oncoprotein BCR-ABL (Breakpoint-cluster region and Abelson leukemia proteins) derived from nRTKs mutation (chromosomal rearrangement) are associated with the development of hematological malignancies, either leukemia, lymphoma, or myeloma via STAT3 signaling [55, 56]. The gene discussed is STAT3; the disease is lymphoma.