STAT3 and cancer: There is considerable literature reporting that STAT3 is constitutively activated in a dozen different cancers including solid tumors (breast cancer [29], cervical cancer [30], colon cancer [31], pancreatic adenocarcinoma [32], esophageal squamous cell carcinoma [33], non-small cell lung cancer [34], ovarian carcinoma [35], et al.)and hematologic tumors (lymphomas [36], acute myeloid leukemia [37], chronic myeloid leukemia [38], et al.).