Oligos5 highly expresses CRYAB, a small heat shock protein, which is implicated in various protein aggregation-related neurodegenerative diseases, such as PD, Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and prion disorders [29] (Fig. 5D). The gene discussed is CRYAB; the disease is amyotrophic lateral sclerosis.