Additionally, Etomoxir (Eto, a CPT1a inhibitor) significantly impaired the OCR (oxygen consumption rate) of parental HCT116 cells incubated with tumor-adipocyte-co-cultured supernatant, particularly in MIIP+/−-derived supernatant cultured cells but not in conventional (McCoy's 5A) cultured cells (Fig. 5i, j). This evidence concerns the gene CPT1A and neoplasm.