An integrated analysis of DNAm and gene expression data identified several DNA methylation-regulated genes associated with asthma severity and lung function in BECs dataset and subset of which including cg01975495 (SERPINE1), cg10528482 (SLC9A3), cg25477769 (HNF1A) and cg26639146 (CD9), cg17945560 (TINAGL1) and cg10290200 (FLNC) were further confirmed in validation AECs dataset. This evidence concerns the gene HNF1A and asthma.