GLUD1 and cancer: We submitted GLUD1 to TIMER to explore its expression in pan-cancer and the result showed that mRNA expression of GLUD1 was decreased in most tumors tissues compared with normal tissues (Fig. 1a), the result was generally consistent with the expression of GLUD1 protein in pan-cancer in CPTAC, and the difference in GLUD1 protein expression between normal and tumor tissues was more pronounced in ccRCC (Fig. 1b).