GLUD1 and hyperinsulinemic hypoglycemia, familial, 4: In ccRCC, GDH1 is translocated from mitochondria to the cytoplasm and degraded following amino acid deprivation or mTORC1 inhibition, and ultimately leads to cellular preservation of nutrients for survival, suggesting that GDH1 plays an important role in the response of ccRCC to amino acid deficiency [15].