We speculated whether GLUD1 might be differentially regulated in tumor and normal tissues, and through the GEPIA website we obtained GLUD1-related Top 100 genes in normal samples of ccRCC, we found that the molecular functions and pathways of these genes were mainly focused on metabolism-related aspects by GO and KEGG analysis (Additional file 1: Fig S1a–d). The gene discussed is GLUD1; the disease is nonpapillary renal cell carcinoma.