Several MHC genes associated with VDM in this investigation (including the marginally replicated HLA-DRA) have been associated with AD (HLA-A, HLA-B, HLA-DRA [61–63]) or showed increased hippocampal (HLA-DMA, HLA-DMB, HLA-DPA1, HLA-DRA [60]) or pre-frontal cortex (HLA-A, HLA-C, HLA-E, HLA-F, HLA-G, HLA-DPB1 [60]) expression in mild AD dementia cases compared to non-demented controls. This evidence concerns the gene HLA-A and Alzheimer disease.