The results, in IVW analysis (OR0.9997;95%CI 0.9996–0.9999; P = 0.0117) and WM analysis (OR0.9997; 95%CI0.9995–0.9999; P = 0.0258), suggested that elevated CD16-CD56 on NK cells was related with a reduced hazard of HCC development. The gene discussed is NCAM1; the disease is hepatocellular carcinoma.