Traditionally, depending on whether or not CD4/CD8 is present, it is divided into two subgroups, namely CD4+NKT and CD8+NKT [50], CD8+NKT cells against malignancy are associated with a Th1-biased response and homologous CD3 T cells, while CD4+NKT are mainly associated with immune regulation [51]. This evidence concerns the gene CD4 and cancer.