Pathways enriched in all the three models included acute phase response signaling, mitochondrial dysfunction, macrophage stimulating protein (MSP)–Recepteur d'origine nantais (RON) signaling in cancer cells pathway, role of hyper-cytokinemia / hyper-chemokinemia in the pathogenesis of influenza, apoptosis, cellular infiltration by granulocytes, immune mediated inflammatory disease, and inflammation of respiratory system components. The gene discussed is MST1R; the disease is influenza.