Foundational basic studies through transgenic mouse models, such as mice overexpressing long-chain acyl- CoA synthetase in the heart [30] and cardiac-specific glycosylphosphatidylinositol-anchored human lipoprotein lipase [31], have demonstrated that ceramide accumulation in cardiac myocytes significantly contributes to the development of cardiomyopathy. Here, LPL is linked to cardiomyopathy.