Although, in both bioinformatics analysis and tissue microarray validation, our results confirmed the poor prognosis of TGFBI in breast cancer, and the functions of TGFBI associated with the TGFβ signaling pathway and the breast cancer microenvironment, yet detailed functions of TGFBI in the regulations of lung metastasis of breast cancer should be further studied. This evidence concerns the gene TGFBI and breast cancer.