TP53 and Familial prostate cancer: The most significant pathways were pathways in cancer (hsa05200) and the PI3K/Akt signaling pathway (hsa04151), followed by the p53 signaling pathway (hsa04115), glutathione metabolism (hsa00480), non-small cell lung cancer (hsa05223) and prostate cancer (hsa05215) (Fig. 5).