In conclusion, we have demonstrated in this study that suppression of GluIIß expression in non-small cell lung carcinoma A549 cells affected expression level of genes encoded for cellular adhesion molecules and increased cell viability and tumor-lysing activity of co-cultured Jurkat E6.1 T cells and PBMCs thus suppression of GluIIß in cancer cells may represent a novel approach of boosting anti-tumor activity of immune cells. Here, GANAB is linked to cancer.