Therefore, Gay et al. (Gay et al. 2021; Gay et al. 2019) defined SCLC with low expression of ASCL1, NEUROD1, and POU2F3 transcription factors and associated with inflammatory gene signatures as a new subtype of the inflamed SCLC subtype (SCLC-I). The gene discussed is NEUROD1; the disease is small cell lung carcinoma.