Meanwhile, Nguyen et al. (Nguyen et al. 2022) also suggested that epigenetic silencing of MHC-I in SCLC resulted in a poor response to ICBs and found that restoring MHC-I cell surface expression in SCLC could recruit and increase immune cell infiltration, leading to a significant increase in cytotoxic and activated CD8+T cells, and enhancing the anti-tumor immune response to ICBs in SCLC. The gene discussed is CD8A; the disease is small cell lung carcinoma.