Our results revealed that the high-risk group had lower TMB and TNB, as well as a lower abundance of immune and stromal cells, including CD8+ T cells, Tfh cells, activated CD4+ T cells, M1 macrophages, dendritic cells, and Treg cells, of which were related to the anti-tumor immunity in immunotherapy35–38. The gene discussed is CD8A; the disease is neoplasm.