Based on the ssGSEA algorithm, we found that a total of 24 pathways were differentially enriched between the two subtypes (Fig. 2g), with most of them upregulated in subtype 1, including pathways related to immune response (e.g., cytokine-cytokine receptor interaction, IL6 signaling, inflammatory response, immunodeficiency, and immunological rejection), tumor metastasis (e.g., epithelial-mesenchymal transition and angiogenesis), and intercellular interaction (e.g., cell adhesion and ECM-receptor interaction). This evidence concerns the gene IL6 and neoplasm.