PRKCSH exhibited positive correlations with distinct cellular processes in different cancers, such as quiescence in acute lymphoblastic leukemia (ALL); with metastasis, DNA repair, and DNA damage in BRCA; with hypoxia in glioma; with stemness and cell cycle in high-grade glioma; with angiogenesis in LUAD; with differentiation and angiogenesis in retinoblastoma (RB); with hypoxia, differentiation and stemness in renal cell carcinoma (RCC). The gene discussed is PRKCSH; the disease is central nervous system cancer.