Spearman’s correlation analysis of gut microbiota and physiological indexes showed that Ligilactobacillus was positively correlated with tumor proliferating factors NF-κB and β-catenin, anti-apoptotic marker Bcl-2, inflammatory factors IL-1β, IL-6 and TNF-α, and negatively correlated with gut barrier related protein MUC2. The gene discussed is BCL2; the disease is neoplasm.