Bacterial infections can trigger the pathological remodeling of bone, inducing the production of RANK-L in osteoblasts and decreasing the expression of OPG, which causes RANK-L to bind to its receptor RANK present on osteoclasts and induce their differentiation and maturation, contributing to bone loss, which is a typical feature of chronic orthopedic infection5,6. Here, TNFSF11 is linked to bacterial infectious disease.