In total, 356 host factors were found enriched in SARS-CoV-2 virions and were thus subjected to the following criteria: (1) involvement in molecular and cellular pathways linked to viral infections, (2) interactions with other virion-associated factors, (3) interaction with viral structural proteins and/or SARS-CoV-2 RNA and (4) presence in other viral particles. This evidence concerns the gene PROS1 and viral infectious disease.