Interestingly, T cells with expanded and contracted clonotypes upon GOLP treatment expressed exhaustion (HAVCR2, TIGIT, LAG3, and ENTPD1) and activation (IFNG and TNFRSF9) marker genes, respectively (Supplementary Fig. 6D), consistent with the characteristics of tumor-reactive CD8+ T cells as previously reported40. The gene discussed is HAVCR2; the disease is neoplasm.