Consistent with human CD8 GZMB+, the human-like CD8 GZMB+ clusters (Cluster0, 1) also had significantly higher Ctla4, Tox and Tox2 expression in the tumor environment injected with Macro CD5L+, while the expression of Pdcd1 (PD1) was not different between the two groups (Fig. 8D). The gene discussed is TOX; the disease is neoplasm.