In another group of experiments, siRNA loaded onto a nano-platform with reductive response characteristics was used to silence monoacylglycerol lipase (MGLL) and the key receptor regulating macrophage phenotype (endogenous cannabinoid receptor-2 CBMQ 2), inhibit production of free fatty acids in pancreatic cancer cells and induce TAM reprogramming to M1, increasing secretion of tumour-killing factors (TNF-α, IL-12), both of which exert anti-tumour effects [114]. This evidence concerns the gene TNF and familial pancreatic carcinoma.