Studies have shown that metastatic mouse renal carcinoma (RECA) cells produce excessive prostaglandin eosin 2 (PGE_2), which inhibits initiation of tumour-specific CTLs; this is achieved by blocking the IFNγ signal between intercellular cell adhesion molecule-1 (ICAM-1) and lymphocyte receptor lymphocyte function-associated antigen (LFA-1) [58]. The gene discussed is IFNG; the disease is neoplasm.