Chen’s group [130] also demonstrated that EGFR-CAR NK-92 cells(second-generation CAR) increased cytolysis and IFNγ production in breast cancer cell lines MDA-MB-231, MDA-MB-468, and MCF-7 (in vitro), and reduced tumor growth in tumor-bearing mice (in vivo). The gene discussed is EGFR; the disease is neoplasm.