Studies have shown that the expression of TNFAIP8L2 is related to the poor prognosis of brain low-grade glioma (LGG), renal chromophobe cell carcinoma (chromophobe renal cell carcinoma) and renal clear cell carcinoma (Kidney renal clear cell carcinoma), and may become a CAR-NK Targets for the treatment of renal cancer [139]. This evidence concerns the gene TIPE2 and chromophobe renal cell carcinoma.