Next, we analyzed the effect of LDLR overexpression on the infection of other alphaviruses, including SFV, BEBV, RRV, MIDV, MAYV, VEEV, and CHIKV, as well as VSV, a rhabdovirus known to use LDLR as the receptor, using EGFP-expressing pseudo-viruses generated using a lentivirus vector (Supplementary Fig. 3a–c). The gene discussed is LDLR; the disease is infection.