As demonstrated in Fig. 3b–d, LDLR lacking the EGF-like modules still supported rGETV-EGFP infection in HEK 293T cells, but a mutant with the LBD domain removed failed to mediate the virus infection (Fig. 3b–d), which was further confirmed by western blot analysis of the expression of viral capsid (Cap) and E2 protein (Fig. 3e). Here, EGF is linked to viral infectious disease.