POLB and hepatocellular carcinoma: It is worthwhile to point out that POLB is a DNA polymerase functionally located in the nucleus, we thus analyzed the cellular location of these downstream genes and found that only clock-associated genes were mostly enriched in the nucleus (Table S9), suggesting the modulation of circadian clock is a critical pathophysiological output of POLB, therefore the POLBR137Q mutant alleviated HCC progression in a circadian-dependent manner, especially at ZT13.