Our team reported that HFD-fed liver specific 5HT2A knock-out (5HT2A LKO) mice showed decreased hepatic steatosis as examined by histology, NAFLD Activity Score (NAS), and hepatic triglycerides (TG) concentrations without affecting the body weight, glucose tolerance, insulin sensitivity, and plasma lipid profiles15. The gene discussed is HTR2A; the disease is metabolic dysfunction-associated steatotic liver disease.