Ectopic WT-Bmal1 and dHLH-Bmal1 increased genes associated with mesenchymal melanoma state, such as Sox9, Fn1, Col1a1, Prrx2, Klf4, Snai2, Twist2, Lmo1 and Axl31 (Fig. 3a). The gene discussed is TWIST2; the disease is melanoma.