In contrast to the indistinguishable in vitro growth rates of these cell lines (Supplementary Fig. 2c), the modest increase of ectopic WT-Bmal1 protein expression in YUMM2.1-WT significantly increased tumor growth as compared to YUMM2.1-EV tumors (Fig. 2b) in C57BL/6 mice. This evidence concerns the gene BMAL1 and neoplasm.