Further, tumor immunophenotyping by flow cytometry (gating strategy: Supplementary Fig. 2i) revealed that YUMM2.1-dHLH tumors had significant decrease in Cd103+ dendritic cells and NK cells and a notable increase in M-MDSCs, M2 macrophages (Cd11b+; F4/80+; Cd11c−; Fig. 2e) compared to YUMM2.1-EV or YUMM2.1-WT tumors. The gene discussed is ITGAX; the disease is neoplasm.