PTEN and melanoma: To further probe the role of Bmal1 in melanoma, we studied another mouse melanoma cell line YUMM2.1, which is derived from transgenic tumors driven by human melanoma-relevant mutations BrafV600E, Pten−/−, Cdkn2a+/−, and BcatSTA/+ (heterozygous for a stabilized mutant β-catenin)21,22.