BMAL1 and neoplasm: However, WT-Bmal1, in contrast to EV or dHLH-Bmal1, could increase tumor growth (Fig. 1l) in vivo, suggesting that Bmal1 may augment tumorigenesis by stabilizing Hif1α protein27 rather than Hif1α mRNA which was not induced (Supplementary Fig. 1j).