HDGF and hepatocellular carcinoma: Notably, Circ-CDYL exhibits high expression levels in early-stage HCC, where it downregulates the expression of Hepatoma-Derived Growth Factor (HDGF) and Hypoxia-Inducible Factor 1 Alpha Inhibitor (HIF1AN) by acting as a ceRNA for both miR-328-3p and miR-892a [19].