Prominent oncogenes and tumor suppressor genes that are affected by CNVs include epidermal growth factor receptor (EGFR), retinoblastoma protein (RB1), and the cellular tumor antigen p53 (TP53), which have pivotal roles in tumorigenesis and are targets in cancer therapy (Ciardiello and Tortora 2008, Lee and Muller 2010). The gene discussed is EGFR; the disease is cancer.