To confirm this finding, we analyzed hepcidin levels in the plasma of 6 patients affected by hemochromatosis, 3 of them homozygous for HFE-p.C282Y and 3 homozygous for HFE-p.C282Y and heterozygous for HIF1A-p.P582S. This evidence concerns the gene HIF1A and hemochromatosis type 1.