Plasma Hepcidin levels were potently suppressed (5.4-fold down-modulation) in HIF1A-p.P582S cases (Fig. 6C; p < 0.0001), in line with our cell-models, hence confirming HIF1A-p.P582S variant as a modifier of HFE-hemochromatosis and possibly explaining why healthy blood donors expressing this variant usually do not show evidence of iron deprivation 33. This evidence concerns the gene HIF1A and hemochromatosis type 1.