PEX1 and peroxisome biogenesis disorder: Finally, in terms of treating retinal dysfunction associated with loss of peroxisomal functions, injection of wild-type PEX1-encoding AAVs into the retina of the PEX1-Gly844Asp mouse model of mild ZSD has recently been demonstrated to improve ocular phenotypes, showing restoration of peroxisome function in retinal cells alone is sufficient to improve retinal dysfunction, and raising this as an intriguing possible therapy to attenuate the visual symptoms experienced by patients suffering from mild ZSD (Argyriou et al. 2021).